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I J Fidler Selected Research

JBT-3002

6/2000Differential regulation of type IV collagenases and metalloelastase in murine macrophages by the synthetic bacterial lipopeptide JBT 3002.
5/2000Intensified regression of colon cancer liver metastases in mice treated with irinotecan and the immunomodulator JBT 3002.
1/2000Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages.

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I J Fidler Research Topics

Disease

29Neoplasms (Cancer)
11/2005 - 01/2000
20Neoplasm Metastasis (Metastasis)
11/2008 - 01/2000
6Prostatic Neoplasms (Prostate Cancer)
11/2008 - 06/2000
6Carcinoma (Carcinomatosis)
10/2000 - 03/2000
5Pancreatic Neoplasms (Pancreatic Cancer)
10/2001 - 01/2000
5Colonic Neoplasms (Colon Cancer)
03/2001 - 03/2000
4Ovarian Neoplasms (Ovarian Cancer)
10/2000 - 01/2000
3Melanoma (Melanoma, Malignant)
08/2003 - 03/2000
3Adenocarcinoma
04/2001 - 12/2000
2Lymphatic Metastasis
11/2005 - 01/2001
2Hyperplasia
10/2001 - 11/2000
2Malignant Pleural Effusion
12/2000 - 03/2000
2Lung Neoplasms (Lung Cancer)
12/2000 - 12/2000
2Ascites
10/2000 - 03/2000
2Disease Progression
08/2000 - 07/2000
1Fibrosis (Cirrhosis)
10/2001
1Body Weight (Weight, Body)
08/2001
1Renal Cell Carcinoma (Grawitz Tumor)
02/2001
1Papillary Adenocarcinoma
01/2001
1Endometrial Neoplasms (Endometrial Cancer)
01/2001
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/2000
1Acidosis
08/2000
1Stomach Neoplasms (Stomach Cancer)
07/2000
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
03/2000
1Adenocarcinoma of Lung
03/2000

Drug/Important Bio-Agent (IBA)

14Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2005 - 03/2000
12Interleukin-8 (Interleukin 8)IBA
08/2003 - 01/2000
9Messenger RNA (mRNA)IBA
10/2001 - 03/2000
9Proteins (Proteins, Gene)FDA Link
03/2001 - 03/2000
5Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
08/2003 - 11/2000
5Cadherins (E-Cadherin)IBA
09/2001 - 03/2000
5NF-kappa B (NF-kB)IBA
07/2001 - 03/2000
4ErbB Receptors (EGF Receptor)IBA
08/2001 - 06/2000
4Matrix Metalloproteinases (MMPs)IBA
02/2001 - 03/2000
4Collagenases (Collagenase)FDA Link
07/2000 - 03/2000
3Interferon-betaIBA
08/2003 - 11/2000
3GemcitabineFDA Link
10/2001 - 06/2000
3vatalanib (PTK787)IBA
10/2001 - 03/2000
3Tyrosine Kinase InhibitorsIBA
10/2001 - 06/2000
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
10/2001 - 03/2000
3Interferon-alpha (Interferon Alfa)IBA
09/2001 - 04/2000
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
08/2001 - 03/2000
3NF-KappaB Inhibitor alphaIBA
07/2001 - 03/2000
3JBT-3002IBA
06/2000 - 01/2000
2Imatinib Mesylate (Gleevec)FDA Link
11/2008 - 03/2000
2AndrogensIBA
11/2005 - 09/2001
2Epidermal Growth Factor (EGF)IBA
11/2005 - 06/2000
2Phosphotransferases (Kinase)IBA
10/2001 - 03/2000
2Tyrosine (L-Tyrosine)FDA Link
10/2001 - 03/2000
2PKI 166IBA
08/2001 - 06/2000
2Formaldehyde (Formol)FDA Link
02/2001 - 03/2000
2ParaffinIBA
02/2001 - 03/2000
2Therapeutic UsesIBA
06/2000 - 01/2000
2Immunologic Factors (Immunomodulators)IBA
05/2000 - 01/2000
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
05/2000 - 01/2000
2LipopeptidesIBA
05/2000 - 01/2000
2Irinotecan (Camptosar)FDA LinkGeneric
05/2000 - 01/2000
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
11/2008
1Docetaxel (Taxotere)FDA Link
11/2008
1AEE 788 (AEE788)IBA
11/2005
1Paclitaxel (Taxol)FDA LinkGeneric
11/2005
1beta CateninIBA
09/2001
1Doxorubicin (Adriamycin)FDA LinkGeneric
09/2001
1pyrimidineIBA
08/2001
1Hydroxyl RadicalIBA
08/2001
1Proliferating Cell Nuclear Antigen (PCNA)IBA
08/2001
1Transcription Factor RelAIBA
07/2001
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
03/2001
1Biological ProductsIBA
01/2001
1CytokinesIBA
01/2001
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2001
1Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
12/2000
1Tissue Inhibitor of Metalloproteinase-2IBA
12/2000
1Transforming Growth Factor alpha (TGF-alpha)IBA
11/2000
1ExotoxinsIBA
10/2000
1immunotoxin LMB-7IBA
10/2000
1Transferrin Receptors (Transferrin Receptor)IBA
10/2000
1Monoclonal AntibodiesIBA
10/2000
1Immunotoxins (Immunotoxin)IBA
10/2000
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
08/2000
1AcidsIBA
08/2000
1Interleukin-8 ReceptorsIBA
07/2000
1Prostate-Specific Antigen (Semenogelase)IBA
06/2000
1Interleukin-15 (Interleukin 15)IBA
05/2000
1Nitric Oxide (Nitrogen Monoxide)FDA Link
05/2000
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
03/2000
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
03/2000
1ChemokinesIBA
03/2000
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2000
1Neutralizing AntibodiesIBA
01/2000

Therapy/Procedure

13Therapeutics
11/2008 - 01/2000
3Oral Administration
08/2001 - 03/2000
2Drug Therapy (Chemotherapy)
11/2005 - 05/2000
1Injections
03/2001
1Nephrectomy
02/2001
1Subcutaneous Injections
01/2001
1Intravenous Injections
12/2000
1Prostatectomy (Retropubic Prostatectomy)
06/2000
1Intraperitoneal Injections
05/2000
1Immunomodulation
05/2000